The Holy Spirit lives in our spirits, and once He comes, He doesn't leave (John 14:16). There is an initial filling when the Holy Spirit first comes. His control and influence over our souls and body does fluctuate proportionally to how well we have our minds renewed to His will (Romans 12:2).
We can be filled more of the Holy Spirit than at other times, even though in our spirits the presence and power of the Holy Spirit does not come and go. Even after we receive the baptism of the Holy Spirit, there will be times when our souls and bodies stray from the leadership of the Him and we need, once again, to be refilled.
In Ephesians 5:18 believers are commanded to "be not drunk with wine...but be filled with the Spirit." Being filled with the Holy Spirit is in the present tense, making it a continual command for the believer. In the book of Acts, the same people who were filled with the Holy Spirit on the day of Pentecost were filled again. Most people don't get drunk on just one drink.
Being filled with the Holy Spirit is not just a one-time experience. There is an initial filling of the Holy Spirit, but many subsequent fillings. Just as drunkenness can change a person's personality and make him or her act totally different, being filled with the Holy Spirit can make us act just like Jesus.